The present study concerns the flora of the Melik and Kaldırım Mountains as well as of their surrounding area. As a result of the evaluation of the plant samples which were collected from the research area between 2008 and 2011, some 944 taxa were identified as taxonomically belonging to 87 different families and 388 genera. Among them, 331 (35.0%) of the total taxa in the field represent Mediterranean elements, 98 (10.4%) Irano-Turanian elements, 50 (5.3%) European-Siberian elements, and 465 (49.3%) constitute multi-regional taxa or taxa whose phytogeographical regions are unknown. The largest family in the research area is that of Asteraceae (117 taxa) and the largest genus is Trifolium (20 taxa) in terms of the number of taxa. Nine new taxa were recorded for the Flora of Turkey grid C3. In addition, 154 (16.3%) endemic taxa were found in the research area. Depending on ecological conditions, the number of hemicryptophytes is the highest among life forms in the study area.